Chemically defined artificial nectars exist for bees. This is needed, as toxicology screens against pesticides and insect growth regulators need in-vitro raised standard animals to control contaminant variables. No one is suggesting an in-vitro reproduction strategy should be pursued for hobbyist hives.
Bees are raised on chemically defined glucose-fructose solutions with varying adjutants of synthetic additions and/or varying degrees of naturally produced royal jelly from field foragers. Entirely artificial larvae food exists (ie. 0% royal jelly)
A paper worth consulting is:
The Taste of Nectar: A Neglected Area of Pollination Ecology
Author(s): Mark C. Gardener and Michael P. Gillman
Source: Oikos, Vol. 98, Fasc. 3 (Sep., 2002), pp. 552-557
Published by: Wiley on behalf of Nordic Society Oikos
Stable URL:
http://www.jstor.org/stable/3547198 .
A university library or college alumni association may provide access to JSTOR archives.
The 2005 paper, is available as a free download, and has a useful bibliography.
Improvement of artificial feeding in a standard in vitro
method for rearing Apis mellifera larvae
http://www.bulletinofinsectology.org/pdfarticles/vol58-2005-107-111aupinel.pdf
This paper should also be consulted
Responses of Honey Bees (Apis Mellifera) to Amino Acid Solutions Mimicking Floral Nectars
David W. Inouye, Gordon D. Waller
Ecology, Vol. 65, No. 2 (Apr., 1984), pp. 618-625
Honey bee-attractive Nectar, invert sugar syrup and HFCS are all very similar, with the exception of microscopic flavor, oil and protein compounds in the nectar. In bulk, there is no gross nutritional difference, on the finer scale one loses flavor from the artificials. I expect the epi-genetic effects of "up-regulation" are still poorly described --- certainly any pollen collection will introduce enormous volumes of the relevant factors (e.g. quercetin), and sterols, oils, and protein are also sourced from the pollen. HFCS has a poor reputation for the presence of the "burnt toast-caramel" contaminants, which are toxic. Better manufacturing control could likely eliminate these from HFCS feed, but they can appear in any heated and mishandled fructose (including natural honey) -- don't feed back the wax melter leavings. The Australian publication on bee nutrition places enormous stress on fresh, species appropriate pollen in the sub mixes -- this is careful empirical observation. Again -- the sugar component are cross replaceable (D-fructose is D-fructose), but the magic is in the very complex pollen contribution, of which a little travels with the nectar as a contaminant.