I guess so, but not in new comb like that. And I have seen plenty of frames of brood that were top to bottom and end bar to end bar w/out and, or hardly any, empty cells. This has usually occured in newly drawn Pierco frames in nuc boxes. But i have seen it in full sized colonies too.You want some spottiness- as I understand it, that is from hygeinic behavior - bees picking out larvae with mites and maybe other diseases.
I don't think that you think this isn't a quality queen, I just think it's interesting that you spend the time counting 150 empty cells when it's obvious the remaining 3,000 or so are filled. I mean, just sayin'...:lpf:i don't want anyone thinking that I think that the frame isn't from a quality queen.
What were your bees cleaning out of 150 cells on one side of this comb?