Terrimyicin is an antibiotic. Like any, the more you use it, the less it becomes effective. I use it in the spring, when the bees are just getting going for the year. I sprinkle a mixture of that and sugar on the top bars. I have been told, using an extender patty is really wasting your money, because as it ages, so does the terimyicyn, and it becomes useless. Sprinkling it is a better dose anyway, and I don't use it in an extended timeframe.
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Dale Richards
Dal-Col Apiaries
Drums, PA