If they have built that comb and bridged between two frames that were spaced too far apart, is there damage done to hive or brood if that is removed? Or should it just be left it?
Even if the frames are spaced correctly, the bees will often build burr comb to bridge the gap in spots. You will also see them build burr comb between boxes, and often lay a row or two of drone brood in this burr comb. When you break the boxes apart, it breaks open this drone brood. (But gives you a good look to see how badly the drone brood is infested with varroa.) When you move frames, it will tear any burr comb between frames. Bees also like some burr comb between boxes to act as a ladder to make it easier to climb to the frame above them.
Don't worry about damage you may do to burr comb. True burr comb should just be ignored. The bees put it there for a reason. If you remove it, you are making them do unnecessary work to replace it. Burr comb is a very small portion of the comb in a hive. Damage to burr comb will only make a minimal impact upon the hive.