Oh, boy, I can see problems ahead. Or should I say, I can see problems lying in dripping ruins on my own feet?
I did something like this (for various reasons). I had some medium frames in a deep box and thought it interesting, maybe even cute, that my enterprising bees drew great arcs of comb below in the open space. I was warned by a friend who knew about this that it wouldn't end well, but I ignored that since I knew lots of people had completely frameless TBH arrangements.
Fast forward to eight days ago on my first post-winter inspection. I opened the top box (the one with wonky arrangement), it looked solid. I pried open the joint between the box below to check for queen cells. None seen, so OK, time to lift the whole wonky-box as a unit to set it gently aside and paw through the lower box first. My husband came out to help as it was HEAVY. We carefully lifted it up to set it aside, and ..... slap, sploosh, down fell most of the unsupported free-form arcs of comb, honey, pollen and BROOD all over my feet. Major panic set in - where was the queen????? I hastily salvaged what I could, rubberbanding in brood and honey comb. No sign of the queen. Got the box back on as fast as possible, and just as I was nudging the last of the frames down, another free-hanging comb arc calved off and slid down onto the frames below. By this time I felt that any more hive-mayhem would only make things worse, so I left it the way it lodged and closed up the hive. But still no sighting of the queen.
I felt just awful because this was completely avoidable if I had only acted on the advice and not allowed this mess to grow. Sure, bees in cavities can build all kinds of marvelous cross-comb architecture and it works just fine. But in a moveable frame/moveable box-style hive, which is subject to rude, unanticipated (by the bees) lifts and pryings, the frames are the exoskeleton of the comb. Without them, you just have a dripping pool of honey, wax and poor little dumped-out larva wiggling pathetically on your sneakers.
I have not been back in to see if I have fresh larva which would prove the continued (miraculous!) health of Queen Iris. I think later this weekend (10 + days from Disaster) I will venture a peek if it's warm enough. Behaviorally, I think the hive is still queenright, but who knows.? It will break my heart if my stupidity cost her her life.
So, um, no, I wouldn't leave a medium comb in a deep for more than the barest minimum time and would regard leaving it there for any extended time (as I did) to be beekeeping malpractice.