Roundup (glyphosate) is relatively safe for most critters if you do not spray it directly on them. Remember it kills all plants so only get it on the weeds
Of course a hoe, weedeater, gloves, mulch are the most bee/environmentally friendly. Nearly all "organic" insecticides are no more than some dish soap diluted with water so save your money and mix your own. It will kill most insects.