I just put the drone frame overnight in the freezer (in a plastic bag), take it out in the morning and let it thaw for about 5 hours (so you don't put something really cold into the hive brood area). I pull out about 15 or 20 or drone pupae per frame to check the number of mites on them (if any), and then I just put the frame back in the hive as is, without scraping open the cappings. They seemed to have no problem cleaning everything out and getting the frame going again.
Some people don't bother freezing, they just scrape the cappings off the frame, knock out the pupae on the ground or to their chickens, and put the frame back in. I have to harden my heart a little more before I can do that (I confess), but I admit it does seem like a more straightforward method.
Either way, you want to check the pupae for mites so it can tell you whether you have a serious mite problem developing or not.