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Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model
Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). In particular, a specific component of bee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. Parkinson disease (PD) is a neurodegenerative disorder characterized by typical motor symptoms (akinesia, rigidity, rest tremor) that result from the progressive loss of dopamine (DA) neurons in the substantia ***** (SN) [1]. Recent studies suggest that bee venom (apis mellifera) can protect dopaminergic (DA) neurons from degeneration Interestingly, two studies reported that the peptide apamin, a specific component of bee venom, can protect DA neurons in a model system of midbrain cultures that mimics the selective demise of these neurons in PD [6],[7].
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061700
 
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