Ultimate success probably depends on the beekeeping environment. Lots of industrialized migratory operations around? The chance of success is low. The ability for bees to adapt depends on a system stable enough to adapt to. The constant bringing of bees together from around the continent, along with their hitchhikers makes for a chaotic adaptive environment. TF or traditional approaches don't have a chance to make headway.
But you don't know until you try. Getting local bees from folks that make their own queens is a good start. From the stories I'm hearing around here, we have some resistance lurking with the local keepers, even though they are unaware of it. We also have some known feral bee hives that have been in existence for a few years. I think these two factors have allowed me to get to where I am in my operation. I also brought in queens from the best source (Saskatraz) I could find. The combination seems to be working. I have queen lines that originate from local stock and some from the Saskatraz stock. I have better 2 year survival this year so I can diversify my queen rearing efforts. I have made and lost lots of nucs. Partly out of my own ignorance as a newer beekeeper. But it allowed me to find the bees that survive.
The next step is dominating the local bee space wherever you are. This means having as many bees as you can handle. This year I will have sites for the first time within flying distance of each other. This I hope will result in more of my queens and drones interacting with each other, and increased stability. But even so, this years bees without this benefit seem to be stronger than ever.