Yes, it's important in the case of the designs MB is discussing. DM1's design is based on an entirely different set of parameters. He mentions up in the post that he knows they'll likely comb it up in spots and is OK with that. I'm looking forward to seeing it built out. it might look cleaner than we think in the end.
If you're looking at 2 parallel pieces of glass with one or two frames depth between, follow MB's advice. One OH I tend at a local nature center is loaded with comb on the front glass because too much space was left. I suggested adjustment a couple of years ago but my contact there really likes the look so we left it. My others are clean. I like being able to see the whole thing clearly.