I've been using the red seed heads from the staghorn sumac for the last couple of years since reading a post on this website. I have never used poisons in my hives for anything, even though mites are present. I have screened bottom boards and use the powdered sugar dusting technique in the fall.
As far as the safety issue goes... I don't use any protective breathing apparatus. The little bit of smoke smells fine and there is plenty of information on the web about the consumption of products from these seed heads including making wine. Here's the link:
Anything in moderation. In fact my father inlaw, a world recognized expert in public health, recently showed me several articles on how small amounts of radiation boost the human immune system.