I have been keeping bees for a lttle over three years.
Before I kept bees I believed myself to be one of those people with an anaphylactic reaction to honey bee stings. Since I am also a professional horticulturist and fruit and veg farmer, protecting myself from stings has been a life long pre-occupation and I always carried Epi-pens, though for decades never used one. I'm in my 60s, so that's a lot of wasted drugs!
Early on in my struggles to keep my cut-out bees in their hive rather than back in the barn walls they came from, I had one evening when we under a tornado watch with an approaching severe thunderstorm when I was determined that I couldn't leave the bees exposed to the wind, so I tried to scoop them out again.
Since it was nearly dark, with a heavy storm approaching and I was workinig on an extension ladder, you can imagine how mad that made the bees and they just lost it - I took dozens of stings, and hundreds and hundreds more stingers were embedded in my clothing and heavy gloves during this foolish task. (Now, I would know the bees would be less harmed by the storm than by my silly effort to "protect" them. I was so clueless!)
My fresh Epi-pen was in my pocket and I was trying to monitor myself for any reaction while still keeping doggedly to my task. When I'd finally moved as many bees as I could, I climbed back down the ladder and realized I was having no reaction at all beyond the pain from the stings themselves.
Since then, I have probably a couple of stings per week during the warm months and maybe one a month during the winter, so pretty much year 'round exposure. During the first year, or so, I got some slight swelling, and bit of itchiness.
Once, in my second summer, I got stung on my wedding ring finger and had such fast swelling I was lucky to get the ring off w/o cutting it off. (The old EMT trick of string and oil saved the day.) Other than that, beyond the sometimes fierce initial discomfort, I rarely get any reaction anymore except sometimes a slight soreness in nearby joints, a sort of arthritis-type reaction during the next 24 hours. (And that's weird because I know some people deliberately try stings as a means of relieving arthritic pain.)
But I generally get no swelling, or itching, or anything, anymore. My dignity is always impaired, though, because I hop around wailing like a baby and cursing like a sailor when I get stung. Just a drama queen, I guess.
Enj.