Time spent monitoring is time wasted. The trick is to know what your manipulations are going to do before you do them because you aren't going to have time to come back in two days and check. You can't be going back to hive 486 to see if moving frame 2 into the middle had the desired effect or not.
So how do you know what manipulations you need to make?
Significant Minority vs Insignificant Majority, 20% of causes produce 80% of the effects.