I put the comb in its natural orientation when I am by myself, but I should report that the queen continues to lay in the comb and the bees build it to fill the frame fairly quickly, regardless of the orientation of the comb in the frame. I don't know how much remodeling of the cell structure the bees actually do, but they do well enough and they don't need any supervision by me....I don't think it matters how you put the comb in the frame, the bees adapt and overcome.
I helped get the bees and comb from three very high pecan trees. The bees in this picture were 25' up (the other two were 28' & 35' high). That ladder is about 14' high.
Apologies for hijacking your thread Drew, can't wait to see your results.