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Thread: Fumagilian-B

  1. #41
    Join Date
    Apr 2004
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    Central CA.
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    432

    Default Re: Fumagilian-B

    At the Feb 5th Delta Bee Club meeting Randy Oliver spoke and said that using Fumagillin may at times make Nosema levels worse. He said a lot of other things about Pristine and Dimilin which is an IGR and a lot of other stuff. Randy talks 60 Mile an hour and I can only listen at 30. There are others on here who were at the meeting, maybe they will chime in. The last thing he said was "see my article in next months ABJ".

    Keith, I told you, you should go.
    Jim

  2. #42
    Join Date
    Feb 2010
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    Applegate, Oregon, USA
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    45

    Default Re: Fumagilian-B

    Regarding nosema control, I noticed something in Keith's video clip that probably has significant benefit to colony health. Keith is shaking bees coming out of winter.......... twice.

    In medical school, one could likely pass through the first couple of days on the surgery ward by simply reciting "The solution to pollution is dilution". This statement relates to the cleansing of open wounds by flushing copiously with sterile saline. No bactericidal agents are used, as these damage viable tissue to a greater extent than they kill germs.

    Keith is adding cohorts of nosema-free bees to his hives by encouraging massive broodrearing. (Those broodnests are three times the size of mine here in Oregon.) As he shakes adults for sale, he is ridding the hive of nosema susceptible individuals. He is getting some of the same effect as moving colonies from their last summer nectar flow before flight has ended, thus cleansing the hive of the more heavily diseased physiologically old foragers.

    Now, I would bet that Keith may also add his subs to hives as they near the end of a honey flow as well. This would complete the cycling of fresh disease-free bees into the hive as disease-laden bees are eliminated.

    This does not suggest that the bees eliminated from the hive are truly disease laden, rather, if a pathogen was to gain entrance into a colony, it's likelihood of effectively establishing itself is diminished by this practice.

    By the way, Keith, what percentage of the hive do you think is removed with each shaking?

    Andrew

  3. #43
    Join Date
    Jan 2005
    Location
    souris, manitoba, canada
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    746

    Default Re: Fumagilian-B

    Keith said"We have a micro-flora builder in our sub which competes with the nosema spores. "

    Is the miro-flora builder a probotic?

    World English Dictionary
    microflora (ˈmaɪkrəʊˌflɔːrə) [Click for IPA pronunciation guide]

    n
    the community of microorganisms, including algae, fungi, and bacteria that live in or on another living organism or in a particular habitat

  4. #44
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    Jan 2005
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    souris, manitoba, canada
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    Default Re: Fumagilian-B

    Some keepers, like me in the north, treat their bees with Fumidil -B loyally every fall............................it seems to help the keeper sleep at nite

  5. #45
    Join Date
    Aug 2002
    Location
    Nehawka, Nebraska USA
    Posts
    43,624

    Default Re: Fumagilian-B

    > Randy Oliver spoke and said that using Fumagillin may at times make Nosema levels worse.
    >it seems to help the keeper sleep at nite

    With a false sense of security...
    Michael Bush bushfarms.com/bees.htm "Everything works if you let it." ThePracticalBeekeeper.com 40y 200h 37yTF

  6. #46
    Join Date
    Jan 2007
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    Manitoba, Canada
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    406

    Default Re: Fumagilian-B

    Quote Originally Posted by irwin harlton View Post
    Some keepers, like me in the north, treat their bees with Fumidil -B loyally every fall
    That was me most years up until a couple of years ago. Some of my hives were tested for nosema in the middle of winter and came back with spore numbers that were through the roof. Bees were collected from under the lid. That investment into fumagillin-B the fall before was sure worth it--NOT.

    The hives wintered fine and build up nicely the following spring. Go figure.

  7. #47
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    souris, manitoba, canada
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    Default Re: Fumagilian-B

    http://www.delta-business.com/Calgar...0Nosema%20.pdf

    This study, I believe was done in 2009/10...................not much new since than,except reports showing spore count spikes up again after treatment, which is not good, this is saying that Fumidil B will in fact encourage a deeper more virile infection after initial treatment

  8. #48
    Join Date
    Feb 2006
    Location
    Herrick, SD USA
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    4,035

    Default Re: Fumagilian-B

    We havent used Fumigilian-B for 3 years now. Of 16 samples pulled by the state late in the summer 10 were negative. The 6 positives averaged 1.52 per million. The treatment threshold that I have heard used before is 5 though I havent any idea how that number was arrived at.
    "People will generally accept facts as truth only if the facts agree with what they already believe."- Andy Rooney

  9. #49
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    Default Re: Fumagilian-B

    > Use of fumagillin may increase the prevalence of N. ceranae and is potentially a factor in replacement of N. apis by N. ceranae in US apiaries.

    Fumagillin treatment is known to reduce microsporidian
    reproduction and is probably useful for protecting weak
    colonies [2], but the antibiotic may have unintended effects on the
    honey bee host, ultimately contributing to increased prevalence
    and pathogenicity of N. ceranae. In addition, the time period of N. ceranae
    hyperproliferation may reverse the benefits gained at the
    beginning of fumagillin treatment, resulting in indistinguishable
    performance between fumagillin treated and untreated hives.

    Huang W-F, Solter LF, Yau PM, Imai BS (2013) Nosema ceranae Escapes Fumagillin Control in Honey Bees. PLoS Pathog 9(3): e1003185.
    Compliments of Peter L Borst post at Bee L

  10. #50
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    Sep 2009
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    Millbury, MA, USA
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    1,653

    Default Re: Fumagilian-B

    Nosema ceranae Escapes Fumagillin Control in Honey
    Bees

    Wei-Fone Huang1*, Leellen F. Solter1, Peter M. Yau2, Brian S. Imai2
    1 Illinois Natural History, Prairie Research Institute, University of Illinois, Champaign, Illinois, United States of America, 2 Roy J. Carver Biotechnology Center, Protein
    Sciences Immunological Resource Center, 307 Noyes Laboratory, Urbana, Illinois, United States of America
    Abstract
    Fumagillin is the only antibiotic approved for control of nosema disease in honey bees and has been extensively used in
    United States apiculture for more than 50 years for control of Nosema apis. It is toxic to mammals and must be applied
    seasonally and with caution to avoid residues in honey. Fumagillin degrades or is diluted in hives over the foraging season,
    exposing bees and the microsporidia to declining concentrations of the drug. We showed that spore production by Nosema
    ceranae, an emerging microsporidian pathogen in honey bees, increased in response to declining fumagillin concentrations,
    up to 100% higher than that of infected bees that have not been exposed to fumagillin. N. apis spore production was also
    higher, although not significantly so. Fumagillin inhibits the enzyme methionine aminopeptidase2 (MetAP2) in eukaryotic
    cells and interferes with protein modifications necessary for normal cell function. We sequenced the MetAP2 gene for apid
    Nosema species and determined that, although susceptibility to fumagillin differs among species, there are no apparent
    differences in fumagillin binding sites. Protein assays of uninfected bees showed that fumagillin altered structural and
    metabolic proteins in honey bee midgut tissues at concentrations that do not suppress microsporidia reproduction. The
    microsporidia, particularly N. ceranae, are apparently released from the suppressive effects of fumagillin at concentrations
    that continue to impact honey bee physiology. The current application protocol for fumagillin may exacerbate N. ceranae
    infection rather than suppress it.
    Citation: Huang W-F, Solter LF, Yau PM, Imai BS (2013) Nosema ceranae Escapes Fumagillin Control in Honey Bees. PLoS Pathog 9(3): e1003185. doi:10.1371/
    journal.ppat.1003185
    Editor: David S. Schneider, Stanford University, United States of America
    Received July 6, 2012; Accepted December 21, 2012; Published March 7, 2013
    Copyright:  2013 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
    unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Funding: This project was supported by Agriculture and Food Research Initiative Competitive Grant no. 2009-85118-05718, from the USDA National Institute of
    Food and Agriculture, and USDA-CSREES Project no. ILLU-875-302-0205249 S-1024. The research was also supported by the Prairie Research Institute, Illinois
    Natural History Survey and Roy J. Carver Biotechnology Center, Protein Sciences Immunological Resource Center at the University of Illinois at Urbana-Champaign.
    The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
    Competing Interests: The authors have declared that no competing interests exist.
    * E-mail: wfhuang@illinois.edu

    full paper available here:
    http://www.apinews.com/en/news/item/download/1317

  11. #51
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    Default Re: Fumagilian-B

    this is better and cheaper than Fumidil-B

    http://www.wvu.edu/~agexten/varroa/2...nch%202010.pdf

  12. #52
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    Jan 2007
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    Manitoba, Canada
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    406

    Default Re: Fumagilian-B

    Irwin have you been doing this and getting similar results?

  13. #53
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    Default Re: Fumagilian-B

    no, but going to try it
    Reports, I have heard have been good
    Last edited by irwin harlton; 04-09-2013 at 09:30 PM. Reason: info added

  14. #54
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    Manitoba, Canada
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    406

    Default Re: Fumagilian-B

    Are you thinking of drenching or adding to feed?

  15. #55
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    Default Re: Fumagilian-B

    drenching and adding to feed

  16. #56
    Join Date
    May 2010
    Location
    Spokane, Washington, USA
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    683

    Default Re: Fumagilian-B

    Ever since I started using that stuff, my bees never had nosema problems.

  17. #57
    Join Date
    Jan 2003
    Location
    Manitoba Canada
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    5,503

    Default Re: Fumagilian-B

    do you mix your syrup 1gallon HBH to 200gallons syrup or do you thin the HBH down some
    Ian Steppler >> Canadian Beekeeper's Blog
    www.stepplerfarms.com

  18. #58
    Join Date
    May 2010
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    Spokane, Washington, USA
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    683

    Default Re: Fumagilian-B

    Ian, I mix 2 gal/200gal for the first gallon of feed the bees receive then the rest are 1/200. Last fall we started using Mann Lake version of HBH.

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