And most of the time we needn't know anything at all about deeper mechanisms. Jacob describes it in the Old testament, the medieval 'put best to best' says it all. Darwin studied pigeon breeders - none of these people had a clue about genes. But they recognised the phenomenem of inherited traits.
So; this is not complicated. And there is little need for anything more complicated. However, given that we have a number-one identified primary enemy -varroa - to which non-treatment beekeeping is 99% directed (non-treatment largely means no varroa treatments) it is often useful and definitely interesting to some to look more closely as well at the mechanisms by which bees become and maintain resistance to varroa. Again, 99% of that conversation is - not all beekeepers understand - basically a simple breeding issue. Breeding (selection) is necessary; treating (an openly mating species) amounts to the very opposite of sound breeding practice.
So the main topic of interest is the way natural selection and deliberate breeding techniques allow treatment-free beekeeping in the face of the presence of varroa.
And the main objective I feel is to explore and discuss these things in a way that is focussed and accessible to as many beekeepers as possible. I try to K.I.S.S.