In my case I have around 400 some hives and I usually put a mite treatment on as I pull the last supers and then not again until Spring, just before apple pollination. Now that I have MAQS on some those will probably not get another treatment until they get down to SC. Whereas the rest will get treated w/ Apigaurd soon and then either before they go South or soon after getting down there, I imagine.

I don't usually go into the brood nest regularly once the hives have been set up so as not to swarm.