Edited to add, I don't break up the brood nest. It can be hard to do with a queen filling every empty cell with an egg. Having observed that I am not sure how much of a problem it would be. at certain times of the year to move the brood nest around. I did not risk it. maybe I will this next spring.
I was told I would be sorry because I had moved brood further way from the honey. that was not the case. every frame of brood has it's own honey and pollen.