I have 2 questions regarding pow. sugar treatment.

1) When you use the pow. sugar treatment does it kill or harm any open larva or capped brood? and 2) I am running 2 deeps with 2 honey supers ,could I remove the honey supers and do the P.S on the brood chamber and then replace the supers. I still have some uncapped honey
but would like to do the treatment.