Taking it nice and slow during an inspection is important. No, it's not necessary to look at every frame...front and back, for signs of "something". Nor is it necessary to find the queen. In fact, slow inspections without looking real hard for the queen may result in more queen sightings than a complete teardown. What is important is to get a general feel for the hive. Kind of a 3-D mental image of what the inside looked like before you opened it up. Where is most of the cluster? Where is the brood? How do the stores look...honey & pollen? Were there any queen cells? Were they swarm cells, supersedure cells or just cups? Any damaged comb? How does the brood pattern look? Is it time for a super?
While these few questions seem like a lot, they're nothing more than what a good observer would be able to notice by pulling and examining a few frames. As said above, you can try to tie your observations of the inside of a hive to what you're noticing by watching the outside. Much can be learned by watching bees at the entrance.
Finally, if you have more than one hive in the yard, look for differences between them. Some differences will exist between types of bees. Others will be based on the maturity of the colony, health, etc. It's often the differences that are informative. For instance, a colony that doesn't have much pollen stored compared to others that are winging pollen in all day could point to a failing or failed queen. Focus on the differences and your inspections will be more productive to you and the bees.
"My wife always wanted girls. Just not thousands and thousands of them......"