Unless you have wildflower’s or other nectar bearing plants growing around your fruit trees by the time you need to spray they will have moved on to other forage areas after your fruit trees are no longer in bloom.
We grow blueberries and one of the most important things I have learned about pest control is not what or how much you spray it’s when you spray. And the first thing you have to figure out is what is the life cycle of the pest you are trying to control. For blueberries, blueberry maggot fly is the most destructive. They have an annual life cycle where they hatch out of the ground, you have a seven to ten day window prior to the start of their reproductive cycle. By using yellow sticky traps for detection I can within a day or so figure out when I need to spray. This has several advantages one you get your biggest knockdown, two I was able to cut down on the number of times I need to spray which benefit many other creatures like honeybees and myself.
Regrettably most sprays that kill pest insects also kill honeybees. You are asking the right questions walking around and seeing if you have a lot of honeybees foraging around you trees is also a good way to see if spraying will harm your bees. If you have natural nectar forage one solution is to keep it mowed down during the time you need to spray so they won’t be attracted to the area.
For good information check out some of the universities in you state that specialize in agriculture, you will probably find useful information for me I tap into Michigan State University. You will find information on all the fruit you are growing there.
The Busy Bee teaches two lessons: One is not to be idle and the other is not to get stung.