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  1. #1
    Join Date
    Apr 2005
    Location
    Salem, Oregon
    Posts
    953

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    October 20, 2005

    FDA Approves TYLAN Soluble for the Control of American Foulbrood in Honey Bees

    The U.S. Food and Drug Administration (FDA) has approved TYLAN (tylosin tartrate) Soluble for the control of American foulbrood (Paenibacillus larvae) in honey bees. This is the first approval for the use of TYLAN Soluble in a minor species (honey bees).

    TYLAN Soluble, a product of Elanco Animal Health, a division of Eli Lilly and Company, Greenfield, Indiana, is already approved for therapeutic uses in chickens and swine and production uses in turkeys.

    TYLAN Soluble is the second approved new animal drug for honey bees that controls American foulbrood (Paenibacillus larvae). FDA reviewed extensive data to ensure the product met all necessary effectiveness, animal health, human food safety, and environmental standards. The approval of this supplemental new animal drug application relied on publicly available safety and effectiveness data contained in Public Master File 5783, which were compiled under the oversight of the National Research Support Project-7 (NSRP-7), a national agricultural research program for obtaining clearances for use of new animal drugs in minor animal species and for special uses. Studies were conducted by USDAÂ’s Bee Research Laboratories. FDA has concluded that the honey derived from honey bees fed tylosin tartrate is safe when the animals are fed according to the approved labeling.

    Additional information on this approval may be obtained by contacting Joan C. Gotthardt, D.V.M., Director, Division of Therapeutic Drugs for Food Animals, FDA, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Place, HFV-130, Rockville, MD 20855, 301 827-7571; E-mail: jgotthar@cvm.fda.gov.
    I have exactly ONE hive more than you.
    That makes my opinion beyond question.

  2. #2
    Join Date
    Sep 2004
    Location
    Devils Lake, North Dakota
    Posts
    9,123

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    Just how effective is it??

    Is resistance an issue??

  3. #3
    Join Date
    Sep 2005
    Location
    Red Bluff, Ca
    Posts
    301

    Post

    I don't think resistance is a issue at this time. TM was good for 40 + years. FB only become resistent after Beekeepers started using (Tera Patties). I have no proof that this caused it only that is when resistsnce started
    Dan

  4. #4
    Join Date
    Jan 2005
    Location
    FRASER VALLEY, BRITISH COLUMBIA
    Posts
    1,338

    Post

    I'm not convinced that Terra Patties caused resistance. Resistance came after packers started importing large volumes of Argentinian honey. Reports of antibiotic resistant AFB came from there earlier on ( not to say that it was not an issue here). What happens to all those drums with2-3 pounds of honey sticking to the sides of the barrel? I know that some of them end up outdoors for the bees to clean up.

    Jean-Marc

  5. #5
    Join Date
    Jun 2004
    Location
    san antonio.texas USA
    Posts
    488

    Post

    Has anyone seen labeled dosage/application instructions yet?

  6. #6
    Join Date
    Aug 2002
    Location
    Evansville, IN, USA
    Posts
    2,837

    Post

    >Has anyone seen labeled dosage/application instructions yet?

    Try Mann Lake. They (are/will be) selling the stuff.

  7. #7
    Join Date
    Jul 2005
    Location
    Perkasie, PA
    Posts
    1,998

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    Resistance is always an issue, and it is more effective than tetracyclines (for the time bein when used in the face of a outbreak).

  8. #8
    Join Date
    Jun 2004
    Location
    san antonio.texas USA
    Posts
    488

    Post

    Mann Lake is not selling TYLAN but hopes to in the future.

  9. #9
    Join Date
    May 2005
    Location
    Whitefield, Maine USA
    Posts
    6,624

    Post

    There's a lengthy article in the latest Bee Culture about Tylan.

    George-
    Dulcius ex asperis

  10. #10
    Join Date
    Jun 2004
    Location
    TAVARES FLA US
    Posts
    193

    Post

    Hi everyone, I havent bought any of the Tylan yet, was just wondering do you still mix it with sugar and what is the mixture? Thanks Take care JJ

  11. #11
    Join Date
    Aug 2003
    Location
    Lancaster, Ky. / Frostproof Fl.
    Posts
    984

    Post

    The small bottle treats 500 gallons of syrup. I forgot the weight but it is about the 1/2 the size of a can of pop and that container is about 1/2 full.

  12. #12
    Join Date
    Aug 2003
    Location
    Lancaster, Ky. / Frostproof Fl.
    Posts
    984

    Post

    Almost forgot....it makes syrup have a bitter taste, but bees still take the syrup. You can always tell when it is present by putting a dropon your finger and licking it....very bitter even at that small a consentration.

  13. #13
    Join Date
    Jun 2004
    Location
    TAVARES FLA US
    Posts
    193

    Post

    Hey, How much tylan to how much syrup and do you treat more than once? Thanks JJ

  14. #14
    Join Date
    Jan 2003
    Location
    Manitoba Canada
    Posts
    5,992

    Post

    Residue is much longer than OXytet, so fall treatmetns are a must!!
    Ian Steppler >> Canadian Beekeeper's Blog
    www.stepplerfarms.com

  15. #15
    Join Date
    May 2002
    Location
    Danbury,Ct. USA
    Posts
    1,966

    Post

    http://www.elancous.com/products/pdf...uble_label.pdf

    The maker says mix with sugar and dust 3X. It's not for use before you get the disease.

    Dickm

    [size="1"][ December 27, 2005, 02:37 PM: Message edited by: dickm ][/size]

  16. #16
    Join Date
    May 2002
    Location
    Danbury,Ct. USA
    Posts
    1,966

    Post

    Sutton beeman,
    Where did you get the data you posted? Just wondering where the 2 approaches came from.

    Dickm

  17. #17
    Join Date
    Jun 2004
    Location
    TAVARES FLA US
    Posts
    193

    Post

    Hi Ian, Yes you are right. I have just talked to a few people about Tylan and you must be very careful. Take care JJ

  18. #18
    Join Date
    Jul 2000
    Location
    NE Calif.
    Posts
    2,303

    Post

    http://www.albertabeekeepers.org/Art...sinLimits.html
    Quote from above article:
    "What does this mean for honey producers? Is it open season to used tylosin freely? Absolutely not! Having now completed several years of trials looking at residues of tylosin in honey, I can virtually guarantee that if an application is not made according to the current fall-applied recommendations, a producerÂ’s honey will exceed the WRL."

    [size="1"][ December 27, 2005, 07:55 PM: Message edited by: loggermike ][/size]

  19. #19
    Join Date
    Apr 2005
    Location
    Fruitland ,Idaho
    Posts
    421

    Post

    I personnally would not feed tylan in syrup. It is also not agood idea to use it the spring it builds up way faster than terramycin and is hard to get rid of unlike terramycin. So use sparingly and be careful

  20. #20
    Join Date
    May 2002
    Location
    Danbury,Ct. USA
    Posts
    1,966

    Post

    >>>I personnally would not feed tylan in syrup.<<

    Not to mention that it seems to be against the law!

    Dickm

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